Angeliki Malliri

CRUK Manchester Institute

Angeliki Malliri is a Professor of Cell Biology at The University of Manchester and a senior group leader at Cancer Research UK Manchester Institute. She obtained her undergraduate degree in Biology from the University of Patras, Greece, and her PhD from the University of Crete, Greece. In 1999, she joined the laboratory of Dr John Collard at the Netherlands Cancer Institute in Amsterdam, The Netherlands. There she developed her interest in cancer cell migration and invasion, prominent features of cancer cells that underlie metastasis, focusing on Rho-like GTPases, small signalling G proteins that constitute a subfamily of the RAS superfamily. At Netherlands Cancer Institute, she also developed an interest in other roles performed by Rho-like GTPases in cancer, demonstrating an essential role for Rho molecule signalling in tumour formation in vivo.

Angeliki joined Cancer Research UK Manchester Institute in 2004 as head of the Cell Signalling group and was promoted to senior group leader in 2010. Her laboratory has focused on cell migration and invasion and their control by Rho-like GTPases. More recently she redirected her team’s research toward lung cancer, focusing on KRAS-mutant lung adenocarcinoma as well as small-cell lung cancer and evaluating Rho-like GTPase signalling as molecular targets in these lung tumour types.