Speakers
Julia Herzen
Multimodal and spectral imaging with conventional laboratory X-ray sources has become widely available in the last decade. The innovations that have made this possible are various phase-contrast techniques, novel X-ray sources and photon-counting, energy-resolving X-ray detectors. By combining complementary multimodal information about the objects under investigation, we can identify and quantify materials in 3D datasets at reduced noise levels (Braig et al., 2020), or even provide numbers on the structural sizes of porosity in bulk samples without directly resolving the structures (Sellerer et al., 2021; Taphorn et al., 2021, 2023). Here, we will review the potential of this quantitative imaging methods by highlighting the recent results on biomedical applications.
Braig, E. M., Pfeiffer, D., Willner, M., Sellerer, T., Taphorn, K., Petrich, C., Scholz, J., Petzold, L., Birnbacher, L., Dierolf, M., Pfeiffer, F., & Herzen, J. (2020). Single spectrum three-material decomposition with grating-based X-ray phase-contrast CT. Physics in Medicine and Biology, 65(18), 185011. https://doi.org/10.1088/1361-6560/ab9704
Sellerer, T., Mechlem, K., Tang, R., Taphorn, K. A., Pfeiffer, F., & Herzen, J. (2021). Dual-Energy X-Ray Dark-Field Material Decomposition. IEEE Transactions on Medical Imaging, 40(3), 974–985. https://doi.org/10.1109/TMI.2020.3043303
Taphorn, K., Kaster, L., Sellerer, T., Hötger, A., & Herzen, J. (2023). Spectral X-ray dark-field signal characterization from dual-energy projection phase-stepping data with a Talbot-Lau interferometer. Scientific Reports, 13(1), 767. https://doi.org/10.1038/s41598-022-27155-1
Taphorn, K., Mechlem, K., Sellerer, T., De Marco, F., Viermetz, M., Pfeiffer, F., Pfeiffer, D., & Herzen, J. (2021). Direct Differentiation of Pathological Changes in the Human Lung Parenchyma with Grating-Based Spectral X-ray Dark-Field Radiography. IEEE Transactions on Medical Imaging, 40(6), 1568–1578. https://doi.org/10.1109/TMI.2021.3061253
