Spiros Makris

Spiros Makris is a senior post-doc at the Stomal immunology lab at the University College London- Laboratory of Molecular Cell Biology (LMCB). He completed his PhD at Imperial College London studying innate immune responses in adult and neonatal models of respiratory infections. Before that he completed an MSc in Molecular Medicine at University College London. Since joining the Acton lab in 2018 he has been working on understanding how the lymph node maintains its organisation at steady-state and during the resolution of inflammation. The resolution of lymph node expansion and return to steady state is an unaddressed question, but perhaps understandably neglected since the immune cells migrate to the site of infection. Responsive lymph nodes need to expand both to accommodate thousands of naïve lymphocytes infiltrating and to provide additional space for their clonal proliferation in response to antigen. Lymph nodes undergo vast increases in organ size during adaptive immune responses and can undergo rapid and yet completely reversible remodelling countless times. Our aim is to understand resident and recruited populations within the lymph nodes, and how cellular interaction drive tissue remodelling and the resolution of inflammation.