Alice Pyne

University of Sheffield, UK

Alice Pyne is a Lecturer in Polymers/Soft Matter & MRC/UKRI Innovation Fellow in the Department of Materials Science and Engineering at the University of Sheffield. Alice has over a decade of experience in scanning probe microscopy, spanning high-speed and high-resolution imaging, probe development and cantilever sensing. Alice’s current research aims to understand how variations in DNA structure can affect fundamental biological processes such as replication and transcription. She uses high-resolution AFM to observe variability in structure and conformation in individual DNA molecules and  to understand how these variations influence interactions with oligonucleotides and proteins, with a long-term view to improved development of therapeutics.