This is a provisional outline programme, provided for guidance purposes only and may be subject to change.
Wednesday 6 September
09:00 – 09:30
Spiros Makris -Podoplanin maintains lymph node architecture and leukocyte spatial organisation
Session 1. Cell adhesion and migration in cancer: mechanisms and therapeutic intervention
09:30 – 09:45
Daniel Lietha - Structure and force activation of focal adhesion signalling Mechanistic insights as guide for allosteric targeting
Short talk
09:45 – 10:00
Francisco M. Vega - Cellular plasticity leading to cell invasion in cancer stem cells
Short talk
10:05 – 10:10
Lene Niemann Nejsum - Aquaporin water channels and regulation of cell migration, adhesion and polarity
Poster flash talks
10:10 – 10:15
Marianne Best - Exploring the migrastatic potential of a pre-clinical p21-activated kinase (PAK) inhibitor in a 3D Pancreatic Cancer co-culture invasion model
Poster flash talks
10:15 – 10:45
Valerie Weaver (UCSF) - 'Interplay between Inflammation, Anti-tumor Immunity and Tissue Tension'
Session 1. Cell adhesion and migration in cancer: mechanisms and therapeutic intervention
11:30 – 12:00
Davide Danovi, KCL, UK - 'Modelling glioblastoma migration with patient-derived cells, human iPSC-derived cortical neural spheroid, and high-content imaging
Session 1. Cell adhesion and migration in cancer: mechanisms and therapeutic intervention
12:00 – 12:15
Jan Brábek - Migrastatics Redirecting R&D in Solid Cancer Towards Metastasis
Short talk
12:15 – 12:30
Charly Brown - Repurposing Therapeutics to Target Pancreatic Cancer Invasion
Short talk
12:30 – 12:35
Karen McGeachy-West, Laser2000 - Fast and Deep 3D Live Cell Confocal Imaging
Techno bite
12:35 – 13:05
Angeliki Malliri - Roles of the RAC1 activators TIAM1 and TIAM2/STEF in non-small cell lung cancer'
Session 1. Cell adhesion and migration in cancer: mechanisms and therapeutic intervention
16:00 – 16:30
Matt de Vries - 3D cell shape determination and morphological drug discovery using geometric deep learning and attention-based multiple instance learning'
Session 2. Imaging approaches for migration research and drug discovery
16:30 – 16:45
Daniel Zicha - Pretesting chemotherapeutic drugs with biopsy cells using Holographic Incoherent-light-source Quantitative Phase Imaging (hiQPI)
Short talk
16:45 – 17:00
Gemma Cairns - CD18-dependent alteration of neutrophil behaviour in the breast cancer pre-metastatic niche
Short talk
17:00 – 17:05
Sanju Ashraf, Nikon - NSPARC – new confocal detector for super-resolution imaging
Techno bite
17:05 – 17:35
Cristina lo Celso - 'Intravital microscopy of healthy and malignant haematopoietic stem and progenitor cells' on web.
Session 2. Imaging approaches for migration research and drug discovery
17:50 – 18:50
Roundtable: "the valley of the death": bridging discovery research to drug development"
Session 3. Roundtable: "the valley of the death": bridging discovery research to drug development
Thursday 7 September
09:00 – 09:30
Antal Rot - Accelerated experimental cancer growth and altered tumour-host interactions in mice with ACKR1-deficient erythroid cells'
Session 4. Cell adhesion and migration in inflammatory and infectious disease: mechanisms and therapies
09:30 – 09:45
Jaime Millan - HARNESSING RHO GTPase ACTIVITY TO REINFORCE ENDOTHELIAL JUNCTIONS AND REDUCE SYSTEMIC INFLAMMATORY PATHOLOGIES
Short talk
09:45 – 10:00
Deandra Belo De Freitas - Autocrine IL-6 drives cell and extracellular matrix anisotropy in scar fibroblasts
Short talk
10:00 – 10:15
Buul J.D. Vaan - Primary adhered neutrophils increase JNK1-MARCKSL1-mediated filopodia to promote secondary neutrophil transmigration.
Short talk
10:15 – 10:45
Aleksandar Ivetic - Endothelial cell permeability: from a novel mechanism to a druggable target
Session 4. Cell adhesion and migration in inflammatory and infectious disease: mechanisms and therapies
11:30 – 12:00
Helen McGettrick - Regulation of Leukocyte Trafficking in Rheumatoid Arthritis – New insights and new therapies
Session 4. Cell adhesion and migration in inflammatory and infectious disease: mechanisms and therapies
12:00 – 12:15
Isabelle Cuthbert - Development of a monoclonal antibody which blocks L-selectin shedding
Short talk
12:15 – 12:30
Yue Yang - In vivo suppression of ezrin Y353 phosphorylation reduces selective aspects of neutrophil function: a potential target for sterile inflammation?
Short talk
12:30 – 12:35
Peter Djali, Phasefocus - Label Free Motility Tracking and Lineage Analysis
Techno bite
12:35 – 13:05
Anne Blangy - Targeting the organization of osteoclast adhesive structures as a strategy to prevent pathological bone loss
Session 4. Cell adhesion and migration in inflammatory and infectious disease: mechanisms and therapies
16:00 – 16:30
Danijela Matic Vignjevic - Cancer-associated fibroblasts actively compress cancer cells modulating their drug resistance and invasion
Session 5. In vitro, ex vivo and in vivo models to study migration in disease
16:30 – 16:45
Aurora Campagna - Generating novel 3D cell models for prognostics and immunotherapy of prostate cancer
Short talk
16:45 – 17:00
Lea Normand - Cancer cells transfer invasive properties through collagen-tracks
Short talk
17:00 – 17:15
Camilla Cerutti - Microfluidic 2D and 3D human organ-specific vasculature models to study circulating cancer cell adhesion and migration in metastasis formation
Short talk
17:15 – 17:45
Daniel Irimia - Probing the anti-fungal functions of neutrophils from patients at risk for invasive fungal infections
Session 5. In vitro, ex vivo and in vivo models to study migration in disease