Postdoctoral Research Associate in Biochemical Neuroscience and Dementia
Imperial College London
The Ye lab invites applications from talented, highly motivated, and ambitious postdoctoral scientists for a Postdoctoral Research Associate (PDRA) position leading one or more projects investigating the relationship between build up and clearance of pathological protein aggregates associated with Parkinson’s disease and how removal of such aggregates may be enhanced as a therapeutic strategy for disease intervention.
The project will investigate proteostasis systems in post-mortem donor samples and quantify the effect of aggregate load on IPSC-derived neurons. You will use a multidisciplinary approach (maintenance and manipulation of IPSC-neurons and established cell lines, super-resolution fluorescence imaging and various biochemical techniques) to unveil the mechansism of proteostasis mechanisms and the effect of therapeutic intervention strategies on pathological aggregates.
This research will be driven in close collaboration with our industry partner Eisai.