Custom CAR Lentiviral Service
Among viral vectors, lentiviral vectors (LVs) have demonstrated exceptional promise as tools for gene therapy due to their efficient gene integration and stable expression of the gene of interest in target cells. Given that integration patterns of LVs have a significantly lower risk of random transgene integration and oncogenic transformation than other viral vectors, the production of a safe and efficient CAR T-cell product using this delivery vehicle is feasible. Importantly, LVs have a lower cost of manufacturing than other viral and nonviral gene delivery approaches. Lentiviral derived vectors also have an advantage of efficiently transducing nondividing as well as dividing cells, and thus can transduce a wide variety of cells, including difficult-to-transduce cells such as hematopoietic precursors, neurons, lymphoid cells, and macrophages.
Created: 29 Oct 2024 09:10:16 AM
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